332 BC

Alexander the Great’s admiral, Hegelochos, expels the tyrants from the Lesbian cities and liberates the island from Persian occupation.

330 – 300 BC

Reconstruction of a new Ionic temple incorporating the older temple in its foundation, eventually becoming associated with the Pan-lesbian Sanctuary of Messon.

350 – 340 BC

The date marks the initial phase of construction of the Theatre of Mytilene, which coincides the monumental formation of the city of Mytilene.

378 BC

Formation of the second Athenian alliance with Mytilene, Mithymna, Antissa and Eresos joining in. They take an active part in Alexander the Great’s campaign.

387 BC

After the Antalkidean Peace, “autonomous” Lesbos is forced to recognize Persian rule. Tyrants are placed in the cities. Eresos sides with the Spartans.
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